The clinical significance is uncertain. Concomitant use may result in additive anticholinergic adverse effects. Carbetapentane; Phenylephrine; Pyrilamine: (Moderate) Drowsiness has been reported during administration of carbetapentane. A weight-based dose of 0.02 to 0.05 mg/kg/dose IV once or twice per day has been reported in children 3 to 12 years. Although specific recommendations are not available from the manufacturer, it would be prudent to avoid anticholinergics in patients taking alosetron. Carbetapentane; Diphenhydramine; Phenylephrine: (Moderate) Drowsiness has been reported during administration of carbetapentane. Avoid also using other medicines that contain acetaminophen (sometimes abbreviated as APAP), or you could have a fatal Use of these drugs together may produce additive effects on the GI track; thereby increasing the risk for toxic megacolon. Blurred vision, constipation, and dry mouth may be more prominent additive effects. Aluminum Hydroxide; Magnesium Hydroxide: (Moderate) Antacids may inhibit the oral absorption of anticholinergics. The concomitant use of benzhydrocodone and anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. [43697] [65299] Infusion rates up to 3.3 mcg/kg/minute have been Extrapyramidal symptoms that may develop after initiation of treatment with antipsychotics are often transient and usually respond to a dose of 1 or 2 mg PO twice daily or 3 times daily, within 1 or 2 days. Aspirin, ASA; Butalbital; Caffeine; Codeine: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant codeine and benztropine use. Codeine; Phenylephrine; Promethazine: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant codeine and benztropine use. Butorphanol: (Moderate) Monitor patients for signs of urinary retention or reduced gastric motility when butorphanol is used concomitantly with an anticholinergic drug. When concurrent use is not avoidable, the patient should be monitored for cognitive decline and anticholinergic side effects. Tapentadol: (Moderate) Tapentadol should be used cautiously with anticholinergic medications since additive depressive effects on GI motility or bladder function may occur. The effects of benztropine on labor and obstetric delivery are unknown. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Meperidine; Promethazine: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant promethazine and benztropine use. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Use of anticholinergics may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Discontinue use of eluxadoline in patients who develop severe constipation lasting more than 4 days. Levodopa: (Minor) Through its central antimuscarinic actions, antimuscarinics such as benztropine can potentiate the dopaminergic effects of levodopa. Codeine; Promethazine: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant codeine and benztropine use. Trihexyphenidyl, while also a drug with limited data, has been reported in use during pregnancy in a few cases. Additive drowsiness may also occur, depending on the anticholinergic agent used. Opiates increase the tone and decrease the propulsive contractions of the smooth muscle of the gastrointestinal tract. Reevaluate the need for benztropine after several days of treatment. Blurred vision and dry mouth would be common effects. In addition, preliminary evidence indicates that chronic anticholinergic use in patients with Alzheimer's Disease may possibly have an adverse effect on cognitive function. a.250mg b.120 mg c.375 mg d. 300 mg e. 200 mg Email: [email protected] Ligue agora! Benztropine might also antagonize some of the effects of the parasympathomimetics. Benztropine may impair mental and/or physical abilities and cause blurred vision due to the anticholinergic effects, thus impairing the performance of hazardous tasks, such as driving or operating machinery. The clinical significance of these potential interactions is uncertain. Acetaminophen; Oxycodone: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant oxycodone and benztropine use. Aspirin, ASA; Carisoprodol; Codeine: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant codeine and benztropine use. Prolongation of the gastrointestinal transit time may be the mechanism of the constipating effect. Opiates increase the tone and decrease the propulsive contractions of the smooth muscle of the gastrointestinal tract. Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as 10 H -Phenothiazine-10-ethanamine, N , N , -trimethyl-monohydrochloride. Tardive dyskinesia may appear in some patients on long-term therapy with phenothiazines and related agents, or may occur after therapy with these drugs has been discontinued. Clinicians should note that antimuscarinic effects might be seen not only on bladder smooth muscle, but also on GI function, the eye, and temperature regulation. Use of these medications together may impact the accuracy of the macimorelin growth hormone test. Revefenacin: (Moderate) Although revefenacin is minimally absorbed into the systemic circulation after inhalation, there is the potential for additive anticholinergic effects when administered with other antimuscarinics. There is no clinically important difference in onset of effects between IM or IV injection, therefore, the manufacturer states that IV administration is rarely necessary.Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Additive drowsiness may also occur. Perphenazine; Amitriptyline: (Moderate) Additive anticholinergic effects may be seen when anticholinergics are used concomitantly with phenothiazines, including perphenazine. The concomitant use of remifentanil and anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. WebName Dosage Strength Route Labeller Marketing Start Marketing End Region Image; 4 Hour Allergy Relief: Tablet: 4 mg/1: Oral: Better Living Brands, LLC: 1992-12-19 This dosage may be repeated every six hours, if required. Atropine; Edrophonium: (Major) The muscarinic actions of edrophonium chloride can antagonize the antimuscarinic actions of benztropine. WebGeneral weight-based dosing for pediatric patients is 0.15 to 0.3 mg/kg/dose PO every 3 to 6 hours as needed. Calcium Carbonate; Magnesium Hydroxide: (Major) Avoid concomitant use of calcium carbonate and anticholinergics. Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Both antidiarrheals and anticholinergics, such as benztropine, decrease GI motility. Acute dystonic reactions generally respond to 1 or 2 mg IV or IM, followed by an oral dose to prevent recurrence. Pediatric dosage. The manufacturer has not conducted specific studies to determine the rate of administration or dilution requirements prior to IV administration. Trospium: (Moderate) Additive anticholinergic effects may be seen when trospium is used concomitantly with other antimuscarinics. Concomitant use may result in additive anticholinergic adverse effects. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including anticholinergics. Concomitant use may result in additive anticholinergic adverse effects. Calcium Carbonate; Famotidine; Magnesium Hydroxide: (Major) Avoid concomitant use of calcium carbonate and anticholinergics. 11,15,16 Appropriate alternative recommendations include a humidifier or vaporizer, hydration, and hard candy. Concomitant use may result in additive anticholinergic adverse effects. Clinicians should generally avoid multiple medications with anticholinergic activity in the patient with dementia. Concomitant use may result in additive anticholinergic adverse effects. Benztropine may cause weakness and inability to move particular muscle groups, especially in large doses. Acetaminophen; Hydrocodone: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant hydrocodone and benztropine use. Olanzapine exhibits anticholinergic activity. The concurrent use of trimethobenzamide with other medications that cause CNS depression, like the anticholinergics, may potentiate the effects of either trimethobenzamide or the anticholinergic. Umeclidinium; Vilanterol: (Moderate) There is the potential for umeclidinium to have additive anticholinergic effects when administered with other anticholinergics or antimuscarinics. Benztropine is contraindicated by the manufacturer for use in neonates, infants, and children under 3 years of age. 3 years and older: Weight-based doses up to 0.05 mg/kg/dose PO, IM or IV, generally not to exceed 1 mg/dose, have been reported.Less than 3 years: Contraindicated. Clinical experience has not identified differences in efficacy or safety relevant to younger adults; however, because geriatric patients may be more sensitive to anticholinergic effects, the dose should be started at the low end of the dosage range and increased only as needed and with close monitoring for adverse events. For this reason, it should be administered with caution during hot weather (ambient temperature increase), especially when given concomitantly with other atropine-like drugs to the chronically ill, a person with alcoholism, those who have central nervous system disease, and those who do manual labor in a hot environment. Some sensitive patients may respond to 0.5 mg/day PO or IM at bedtime. Atropine may be used to offset bradycardia in cholinesterase inhibitor overdose. These can be additive with other anticholinergics. Additive drowsiness may also occur, depending on the anticholinergic agent used. Some of the common selective antimuscarinic drugs for bladder problems, (such as oxybutynin, darifenacin, trospium, fesoterodine, tolerodine, or solifenacin), do not routinely cause problems with medications used for dementia, but may cause anticholinergic side effects in some patients. The dosage is 8 mcg/kg/day, and the clients weight is 7.2 kg. We do not record any personal information entered above. Avoid chronic administration of antimuscarinics along with prokinetic agents under most circumstances. Anticholinergics may decrease gastric motility and increase the transit time of solid oral dosage forms of potassium chloride leading to prolonged contact with the gastrointestinal mucosa. Benztropine is absorbed from the GI tract after oral administration; however, a small part of the dose may pass through the GI tract unchanged into the feces. WebDrugs.com is the most popular, comprehensive and up-to-date source of drug information online. Perphenazine: (Moderate) Additive anticholinergic effects may be seen when anticholinergics are used concomitantly with phenothiazines, including perphenazine. Opiates increase the tone and decrease the propulsive contractions of the smooth muscle of the gastrointestinal tract. Phentermine; Topiramate: (Moderate) Monitor for decreased sweating and increased body temperature, especially in hot weather, during concomitant use of topiramate and other drugs that predispose persons to heat-related disorders, such as anticholinergic medications. Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. May be administered without regard to meals. Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. California voters have now received their mail ballots, and the November 8 general election has entered its final stage. Trimethobenzamide: (Moderate) Trimethobenzamide has CNS depressant effects and may cause drowsiness. Patients who are receiving anticholinergics at the time of stimulation testing may be hyporesponsive to secretin stimulation and produce a false result. Calcium Carbonate; Magnesium Hydroxide; Simethicone: (Major) Avoid concomitant use of calcium carbonate and anticholinergics. Olanzapine; Fluoxetine: (Moderate) Additive anticholinergic effects may be seen when olanzapine and anticholinergics are used concomitantly; use with caution. Monitor for symptoms of urinary difficulties or urinary retention. There are no data in the published literature that affirm or contraindicate the use of benztropine in pregnancy for treating movement disorders, such as Parkinson's disease, or as a prophylactic for extrapyramidal effects in conjunction with antipsychotic use. Calcium Carbonate; Simethicone: (Major) Avoid concomitant use of calcium carbonate and anticholinergics. Per the manufaturer, avoid concomitant administration of umeclidinium with other anticholinergic medications when possible. [43703] Usual dosage range: 0.05 to 0.4 mcg/kg/minute (weight-based) or 2 to 4 mcg/minute (flat-dose). Convulsions should be treated with a short-acting barbiturate given intravenously and carefully titrated for the smallest effective dosage. Clinicians should note that anticholinergic effects might be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Benztropine, like other anticholinergic medications, should be avoided in patients with closed-angle glaucoma because the drug can induce cycloplegia and mydriasis, resulting in increased intraocular pressure. Additive drowsiness may also occur. Lubiprostone: (Moderate) Antimuscarinic drugs can promote constipation and pharmacodynamically oppose the action of drugs used for the treatment of constipation, such as lubiprostone. Buprenorphine; Naloxone: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant buprenorphine and benztropine use. Patients should be advised to report gastrointestinal complaints, fever or heat intolerance promptly. Avoid drugs with strong anticholinergic properties in the following conditions due to the potential for symptom exacerbation or adverse effects: dementia/cognitive impairment (drug-induced CNS effects), delirium/high risk of delirium (possible new-onset or worsening delirium), or lower urinary tract symptoms/benign prostatic hyperplasia in men (urinary retention or hesitancy). Antacids may interfere with the absorption of anticholinergics. Benztropine is administered orally and parenterally. Prolongation of the gastrointestinal transit time may be the mechanism of the constipating effect. Anxiolytics; Sedatives; and Hypnotics: (Moderate) CNS depressants, such as anxiolytics, sedatives, and hypnotics, can increase the sedative effects of benztropine. However, guaifenesin has not been proven effective against cough in patients with common cold symptoms. Initially, 0.5 to 1 mg/day PO or IM at bedtime. According to the manufacturer, the safe use of benztropine during pregnancy has not been established. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Additive anticholinergic effects may be seen when MAOIs are used concomitantly with antimuscarinics. Topiramate: (Moderate) Monitor for decreased sweating and increased body temperature, especially in hot weather, during concomitant use of topiramate and other drugs that predispose persons to heat-related disorders, such as anticholinergic medications. While some patients may benefit from this interaction, clinicians should be ready to decrease doses of levodopa if benztropine is added. Benztropine might also antagonize some of the effects of neostigmine Olanzapine: (Moderate) Additive anticholinergic effects may be seen when olanzapine and anticholinergics are used concomitantly; use with caution. Additive drowsiness may also occur. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. This is apparently a result of a decrease in gastrointestinal motility and rate of stomach emptying by the antimuscarinic agent. Consider additional testing and clinical assessments for aid in diagnosis. WebPhenobarbital causes a depression of the body's systems, mainly the central and peripheral nervous systems.Thus, the main characteristic of phenobarbital overdose is a "slowing" of bodily functions, including decreased consciousness (even coma), bradycardia, bradypnea, hypothermia, and hypotension (in massive overdoses). It is not intended to be a substitute for the exercise of professional judgment. Concomitant use may increase the risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. The typical dosage of Symbicort for children ages 6 to 11 years with asthma is two puffs of the 80-mcg/4.5-mcg strength of Symbicort twice a day. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including anticholinergics. Per the manufacturer, avoid coadministration. Tenapanor: (Moderate) Anticholinergics can promote constipation and pharmacodynamically oppose the action of drugs used for the treatment of constipation or constipation-associated irritable bowel syndrome, such as tenapanor. [43697] Titrate by 0.02 mcg/kg/minute (or more in emergency cases) to clinical response. Extrapyramidal symptoms that may develop after initiation of treatment with antipsychotics are often transient and usually respond to a dose of 1 or 2 mg PO twice daily or 3 times daily, within 1 or 2 days. Inhaled respiratory antimuscarinics, such as ipratropium, are unlikely to interact with tegaserod. Concomitant use may result in additive anticholinergic adverse effects. Use of olanzapine and other drugs with anticholinergic activity can increase the risk for severe gastrointestinal adverse reactions related to hypomotility. The concomitant use of pentazocine and anticholinergic medications may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Levorphanol: (Moderate) Monitor patients for signs of urinary retention or reduced gastric motility when levorphanol is used concomitantly with an anticholinergic drug. Parceira e Revenda Autorizada FortiSwitch 1024D, a TND Brasil oferece servios de instalao, implantao, migrao e comercializa firewalls UTM, com equipe comercial certificada oferece os melhores preos, valores e condies do mercado.Seg - Sex 07:00-20:00. Sufentanil: (Moderate) Monitor patients for signs of urinary retention or reduced gastric motility when sufentanil is used concomitantly with an anticholinergic drug. Atropine may be used to offset bradycardia in cholinesterase inhibitor overdose. Ibuprofen; Oxycodone: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant oxycodone and benztropine use. Loxapine: (Moderate) Loxapine has anticholinergic activity. Hydrocodone: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant hydrocodone and benztropine use. Tegaserod: (Major) Drugs that exert significant anticholinergic properties such as antimuscarinics may pharmacodynamically oppose the effects of prokinetic agents such as tegaserod. Birth to 1 month: 16.25 mg orally once Over 1 month to 3 years: 32.5 mg orally once Over 3 months to 12 years: 65 mg orally once Over 12 years; weight less than 150 pounds (68.18 kg): 65 mg orally once Over 12 years; weight 150 pounds (68.18 kg) or greater: 130 mg orally once Comments: WebPediatric renal dosage adjustments based on a usual dose in pediatric patients of 25 to 50 mg/kg/day PO divided every 6 hours Guaifenesin; Phenylephrine: is considered to be less than 1% of the maternal weight-adjusted dose. Potassium Bicarbonate: (Moderate) Use anticholinergics, such as benztropine, and concomitant solid oral dosage forms of potassium chloride with caution due to risk for gastrointestinal mucosal injury. Chronic ingestion of doses ranging from 70 mg to 1600 mg daily - which is four to 100 times the recommended dose - resulted in life-threatening cardiac adverse reactions, including QT/QTc and QRS interval prolongation, Torsades de Aluminum Hydroxide; Magnesium Trisilicate: (Moderate) Antacids may inhibit the oral absorption of anticholinergics. Codeine; Guaifenesin: (Moderate) Monitor for signs of urinary retention or reduced gastric motility during concomitant codeine and benztropine use. Particular muscle groups, especially in large doses generally respond to 1 mg/day PO or at... Be treated with a short-acting barbiturate given intravenously and carefully titrated for the exercise of professional judgment Phenylephrine: Major! Of drug information online benztropine can potentiate the dopaminergic effects of levodopa if is. The constipating effect acetaminophen ; Oxycodone: ( Major ) avoid concomitant use may increase risk. 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